Acute and sub-acute toxicity of Commiphora swynnertonii extracts: an experimental study on albino mice and rats

The acute and subacute toxicity of Commiphora swynnertonii extracts on albino mice and rats was verified. For the acute toxicity study, oral administration of C. swynnertonii hexane and chloroform extract with doses of 500, 1000, and 2000 mg/kg body weight induced no treatment-related signs of toxicity in the animals during the 14 days of the experimental period. In the sub-acute toxicity, C. swynnertonii hexane extract showed a significant decrease in mean corpuscular volume (MCV), hematocrit (HCT) and a significant increase in Mean platelet volume (MPV). A significant decrease in aspartate aminotransferase (AST) and creatinine was also observed. In the rats treated with C. swynnertonii chloroform extract, the signif icant change in white blood cell (WBC), Red blood cell (RBC), Mean corpuscular volume (MCV), Mean hemoglobin concentration (MCH), Mean platelet volume (MPV) and hemoglobin (Hb) were observed.The significant change in alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphate (ALP), creatinine, albumin and bilirubin was also observed.